While CAR(2448)L-BBz T cells mediated cytotoxicity against target tumour cells even at low E:T ratios, control CAR(αCD19)L-BBz T cells were incapable of inducing cytotoxicity against target tumour cells even at E:T ratios as high as 32:1 (Figure 3a), thereby suggesting the sensitivity of CAR(2448)L to ANXA2+ cells. This evidence concerns the gene ANXA2 and neoplasm.