A high variability of molecular and cellular changes was observed, as there was no similar pattern of genetic/non-genetic alterations among eleven investigated resistant cell lines, including phenotypic changes in expression/activity of crucial melanoma regulators e.g., MITF, AXL, NGFR, AKT, ERK1/2, and SOX2 (Figure 7 and Figure S2). This evidence concerns the gene SOX2 and melanoma.