Several de novo mutations (G379R, Y357H, R339G, S337N, S303 frameshift) in RBMX that span the RNA-interacting domain of RBMX [92] were found in our study, but only one of them S303fs+/− was present in resistant melanoma cell lines with elevated activity of AKT (21_TRAR, 28_TRAR, 29_PLXR). The gene discussed is AKT1; the disease is melanoma.