Disturbances in F2 (thrombin), F5 (coagulation factor 5) and other genes such as PROC (protein C), SERPINC1 (serpin family C member 1) and PROS1 (protein S) can produce both autosomal-dominant and autosomal-recessive patterns of inheritance of blood clots in families (https://www.omim.org), and more studies are required to possibly differentiate their role in arterial and venous thromboses impacted by age of onset in both PWS patients and obese controls. This evidence concerns the gene SERPINC1 and Prader-Willi syndrome.