In line with this study, among the 11 BMI/obesity-associated SNPs in European children found to be significant in Central Mexican children, other SNPs in three of those genes contributed to BMI/obesity susceptibility in Mexican children from Mexico City (GNPDA2 rs10938397; MC4R rs17782313, rs17782313, rs2168708, rs28753167; FAIM2 rs7138803 [8,10,11]). The gene discussed is MC4R; the disease is obesity due to melanocortin 4 receptor deficiency.