Several genes have been found to underlie the inherit form of FSGS; the spectrum of these genes is wide, ranging from those responsible for slit diaphragm architecture to those responsible for cytoskeleton, including NPHS1, NPHS2, NPHS3, CD2AP, Myo1E, ACTN4, INF2, and TRPC6 [126]. This evidence concerns the gene TRPC6 and focal segmental glomerulosclerosis.