TRPC6 and focal segmental glomerulosclerosis: Although TRPC6 is not the only gene whose mutations are attributed to the FSGS, podocyte-specific overexpression of WT or two GOF mutants, P111Q and E896K (corresponding to P112Q and E897K of human TRPC6), was sufficient to cause FSGS in mice, which means TRPC6 is essential for FSGS [143].