SMYD3 and colorectal cancer: In agreement with the observation that SMYD3 is over-expressed in colorectal cancers, a study on 117 pairs of CRC and para-tumor tissues showed that the SMYD3 promoter is significantly hypomethylated in CRC when compared to the para-tumor tissues, suggesting that promoter hypomethylation may be involved in SMYD3 upregulation in certain types of cancer [25].