SMYD3 and familial pancreatic carcinoma: Interestingly, SMYD3 knockdown by RNAi has been reported to affect cell proliferation in HCC, BrCA, cervical cancer, EC, CRC, lung adenocarcinoma and KRAS-driven pancreatic cancer cell lines [15,16,43,49,50,51,52,53,54,55,56,57].