On the other hand, female carriers of any rare missense ATM variant, who received radiation therapy for their first breast cancer, had a significantly elevated contralateral breast cancer risk compared to unexposed women (RR = 2.8 for <1.0 Gy dose and RR = 3.3 for ≥1.0 Gy dose to the contralateral breast). The gene discussed is ATM; the disease is breast carcinoma.