In lieu of the lactate-mediated NDRG3 signaling, NDRG3 provokes anti-apoptotic processes during the hypoxia postcondition by regulating adenosine A2a receptors [26], activates Src phosphorylation in colorectal cancer progression [27], and promotes hepatocellular carcinoma metastasis via regulating turnover of β-catenin [28]. The gene discussed is NDRG3; the disease is colorectal cancer.