In an experimental model of autoimmune encephalomyelitis (EAE), an inflammatory disease of the central nervous system where both M1 (IFN-γ) and M2 (IL-4) cytokines are present, forskolin deviates this balance favoring the M2 phenotype [30], suggesting that cAMP-induced polarization might depend on the microenvironment. The gene discussed is IFNG; the disease is central nervous system disorder.