Moreover, DSF/Cu was reported to induce significant cell cycle arrest and apoptosis, cause the disturbance of the ROS balance, and activate the stress-related ROS-JNK pathway as well as downregulate the NF-E2-related factor-2 (Nrf2) and Nuclear factor-кB (NF-кB) pathways in some tumor cells [12,13,14]. The gene discussed is NFE2L2; the disease is neoplasm.