HLCSC was certified by endorsing companies to exert cancer stem cells properties, including markers expressions (CD133, aldehyde dehydrogenase (ALDH), stage-specific embryonic antigen 3/4 (SSEA3/4), alkaline phosphatase, octamer-binding transcription factor 4 (OCT4) and CD43), and in vivo tumorigenicity (<1000 cells). The gene discussed is SPN; the disease is cancer.