On the other hand, fructose produced a vast amount of glucose, inducing insulin resistance and ATP depletion, resulting in increased low energy index ‘AMP/ATP’, which, together with the adiponectin, raised by Antrodan stimulated AMPK phophorylation, the increased pAMPK in turn stimulated the NAD+/NADH ratio, and induced expression of Sirt1. The gene discussed is SIRT1; the disease is Insulin resistance.