The fungi polysaccharide, Antrodan, a β-glucan isolated from A. cinnamomea mycelia, has shown its beneficial effects against NAFLD development by suppressing plasma MDA, GOT, GPT, total cholesterol, triglycerides, glucose, insulin, upregulating adiponectin, leptin, pAMPK, Sirt1, and downregulating PPARγ and SCEBP-1c, which apparently have covered a complete spectrum of therapeutic benefits to alleviate the liver injuries. This evidence concerns the gene ADIPOQ and metabolic dysfunction-associated steatotic liver disease.