Next, in the tumor metastasis model experiments, as Figure 6F1-a, b showed, green area were metastatic tumor from circular pancreatic cancer cells, which were from tail vein injection, and lung metastasis occurred in 1 of the 8 SCID mouse in PANC1_KD1 cells (12.5%), which occurred in 6 of 8 SCID mouse in PANC1_NC cells (75%), that mean FHL3 knockdown decreased the lung metastasis from circular tumor cells more than 50%. Here, FHL3 is linked to pancreatic neoplasm.