Interleukin-6, CCL2, TGF-β1, and colony-stimulating factor 1/macrophage colony-stimulating factor immunomodulatory cytokines (Fisher et al., 2014, Mantovani et al., 2004, Qian et al., 2011, Roca et al., 2009) regulated by ROCK-myosin II (Georgouli et al., 2019, Le Dreau et al., 2010) were upregulated in group 1 MAPKi-resistant melanomas (Figure S8M). The gene discussed is IL6; the disease is melanoma.