PTEN and melanoma: Similar results were observed in other human and mouse melanoma cells and other MAPKi, including BRAFV600E (WM983A, WM983B, 4599) (Figures 1D, 1E, S1A, and S1B), BRAFV600E/Pten-null 690cl2 (Figures 1F and S1C) and NRASQ61L/R (D04, MM485) (Figures 1F, S1D, and S1E) cell lines.