Similar to Ogg1-/- mice, mice that were knocked out for the DNA repair proteins alkyladenine DNA glycosylase (Aag), AlkB homology (Alkbh)2 or Alkbh3 were all greatly sensitized to the development of severe ulcerative colitis, following DSS treatments [94, 95]. Here, XRCC6P5 is linked to ulcerative colitis.