Similar to Ogg1-/- mice, mice that were knocked out for the DNA repair proteins alkyladenine DNA glycosylase (Aag), AlkB homology (Alkbh)2 or Alkbh3 were all greatly sensitized to the development of severe ulcerative colitis, following DSS treatments [94, 95]. The gene discussed is ALKBH3; the disease is ulcerative colitis.