MYC and neoplasm: Of note, one of the major transcriptional targets of BRD4 is Myc, and downregulation of Myc is considered to be one of the key anti-tumour actions of JQ1 (Delmore et al. 2011, Puissant et al. 2013, Bandopadhayay et al. 2014, Wong et al. 2014, Coude et al. 2015, Li et al. 2016).