SLC17A6 and autosomal dominant cerebellar ataxia: These connections are essential for PC function, and dysfunction or loss of these connections, particularly the VGLUT2+ excitatory synapses from the climbing fibers, has been shown in various mouse models of SCA to be linked to pathology and disease progression (Duvick et al., 2010; Ebner et al., 2013; Furrer et al., 2013; Smeets and Verbeek, 2016; Smeets et al., 2015).