A missense variant in SCN5A (the gene coding for Nav1.5), associated with Brugada syndrome, which causes an amino acid substitution (E1053K) in the Nav1.5 ankyrin-binding domain, has led to the identification of a key role for AnkG in targeting Na+ channels to the ICD of cardiac myocytes (Mohler et al., 2004). This evidence concerns the gene SCN5A and Brugada syndrome.