PTPRK and lung adenocarcinoma: In the H1703 human lung adenocarcinoma cell line, knockdown of PTPRK enhanced Wnt3a induced signaling in Topflash reporter assays (Figure 1A and Figure 1—figure supplement 1A) as well as expression of the endogenous Wnt target gene AXIN2 (Figure 1B and Figure 1—figure supplement 1B).