Increased TSP1 levels are associated with many kinds of cardiovascular diseases, including pulmonary hypertension (PH), idiopathic interstitial pneumonia and aging (Ide et al., 2008; van Almen et al., 2011; Kaiser et al., 2016; Kumar et al., 2017; Rogers et al., 2017). This evidence concerns the gene THBS1 and pulmonary arterial hypertension.