CCN1 and colorectal carcinoma: In CRC, Katoh et al. [50] discovered that HOPX up-regulated the WTAP and PRDX2 genes and down-regulated FOS, EMP1, SLC2A3, CYR61, and EPHA2 genes by DNA microarrays, while down-regulation of EPHA2 and CYR61 were shown to reduce angiogenesis in vivo by HOPX expression [50].