HOPX and acute myeloid leukemia: In contrast with heavy methylation in solid cancers [12,55–57,61,62], Lin et al. [63] found that the promoter region of HOPX was barely methylated in leukemic cells from acute myeloid leukemia (AML) patients, and patients with higher HOPX expression had a lower complete remission rate and shorter survival through analyzing HOPX and global gene expression patterns in 347 newly diagnosed de novo AML patients [63].