EZH2 and mesenchymal cell neoplasm: The proneural/neural subtype enriched for DLL3, OLIG2, ASCL1, PDGFRA, IDH1, and PROM1; the classical subtype enriched for FOXO3, NES (Nestin), EGFR and AKT2; and the mesenchymal subtype enriched for CD44 (SSEA1), CHI3L1, NF1, TIMP1, and TGFβ. 39 Notably, it was recently suggested that EZH2 is enriched in the proneural subtype and BMI1 in the mesenchymal subtype.40 Hence, proneural tumors were apparently resistant to BMI1 inhibition using PTC596, and mesenchymal tumors apparently resistant to EZH2 inhibition using two distinct inhibitors.