EZH2 and glioblastoma: Most notably however, prolonged Ezh2 inactivation causes a loss of the H3K27me3 mark, which induces an activation of some pluripotency markers, resulting to a cell fate change and an aggressive tumor transition.60 Thus, loss of H3K27me3 mark in GBM is predictive for a transition towards a more immature and aggressive phenotype.