Transcription factors (TFs), such as SOX2 and OLIG2, have been reported as key molecular cues for gliomagenesis and tumor maintenance.4,11,12 More specifically, TLX, ZFHX4, and MLL5 are TFs and chromatin remodelers overexpressed in glioma CSC population and important for their self-renewal.13–15 Although the interconnection between these factors remains unclear, we can hypothesize that CSC identity relies on a self-sustaining network of TFs. The gene discussed is SOX2; the disease is central nervous system cancer.