ESR1 and endometrial cancer: In contrast, Type II endometrial cancer is associated with serous, clear cell or grade 3 endometrioid histology, loss of ER/PR, black race, absence of unopposed estrogen, presentation at later stage, reduced E-cadherin expression, aneuploidy, mutations in p53 and HER2/Neu overexpression (Bokhman, 1983, Matthews et al., 1997, Kandoth et al., 2013, Zhao et al., 2013).