Recently, using an integrated genomic, epigenomic, transcriptomic and proteomic approach, The Cancer Genome Atlas (TCGA) Research Network provided compelling evidence that endometrial cancers result from heterogeneous somatic mutations and, accordingly, classified endometrial cancers into four categories: (1) polymerase epsilon (POLE)-ultra-mutated, (2) microsatellite instability hyper-mutated, (3) copy-number low and (4) copy-number high, serous-like (Kandoth et al., 2013). The gene discussed is POLE; the disease is endometrial cancer.