The pathogenesis of ABC DLBCLs was believed to be related to activation of the NF-κB signaling pathway via the B-cell receptor (BCR) pathway, but recent studies demonstrated that NF-κB may be expressed in both ABC and GCB DLBCL subgroups and is an adverse prognostic factor [7, 12–20]. The gene discussed is NFKB1; the disease is diffuse large B-cell lymphoma.