IL6 and non-Hodgkin lymphoma: In vitro studies conducted by Malaponte et al. [75] demonstrated that OPN, but not IL-6, stimulation was associated with increased MMP-9 and MMP-2 secretion and activation, suggesting that higher levels of IL-6 found in NHL and their role in proliferation, invasion, and migration of lymphoma cells may probably be attributed to the activation of other molecular pathways.