Interestingly, Yu and coworkers showed that Kindlin-2 binds to β-catenin to promote tumor cell invasion and progression.36,37 Likewise, Lin et al. showed that Kindlin-2 accelerates hepatocellular carcinoma invasion and metastasis by upregulating Wnt/β-catenin signaling.38 Thus, Kindlin-2 can upregulate β-catenin through interactions with the latter and through an indirect mechanism involving sclerostin downregulation. The gene discussed is SOST; the disease is hepatocellular carcinoma.