Thus, metformin reduces ischemic injury by improving the level of MDA, inhibiting the expression of SOD and at the same time activating the lncRNA-H19/miR-148a-3p/Rock2 axis, inhibiting Nrf2/HO-1 signaling pathway downstream of expression, and decreasing oxidative stress after cerebral ischemia injury. The gene discussed is HMOX1; the disease is Cerebral ischemia.