HIF1A and cancer: One of such tools is hypoxia-inducible factor 1 (HIF-1) consisting of two subunits HIF-1α and HIF-1β that regulate the expression of genes implicated in metabolic reprogramming with the involvement of GLUT1, angiogenesis, antiapoptotic mechanisms, stem cell renewal, invasion, and metastasis as well as therapeutic resistance of cancer cells [94, 95].