NFE2L2 and cancer: In addition, redox-sensitive transcription factors, including Nrf2 and HIF-1α, could also be activated to improve the action of antioxidants as well as to trigger the elevation of cell survival molecules such as the antiapoptotic protein Bcl-2 (B-cell lymphoma 2) and AKT (protein kinase B or PKB) [25]; the adaptive mechanism established by cancer cells in ROS response activates resistance to different cancer treatments.