In this study, we evaluated, for the first time, the inducer of Nrf2 or MT alone and in combination to show that (1) BSE or Zn each provide some degree of protection from IH-induced cardiomyopathy and (2) compared with activators of Nrf2 or MT alone, the combination provides more significant protection from IH-induced cardiomyopathy. The gene discussed is MCAT; the disease is isolated hemihyperplasia.