A high level of MUC1 expression (T3/T4 vs. T1/T2: OR = 1.79, 95% CI = 1.41–2.26, P < 0.00001) was associated with deeper invasion in patients with CRC, but the association between MUC5AC and MUC2 expression and depth of invasion was not significant. This evidence concerns the gene MUC5AC and colorectal carcinoma.