A high level of MUC1 expression was associated with distant metastasis (positive vs. negative: OR = 2.47, 95% CI = 1.47–4.13, P = 0.0006) and lymphatic invasion (positive vs. negative: OR = 3.39, 95% CI = 1.69–9.14, P = 0.001) in patients with CRC. The gene discussed is MUC1; the disease is colorectal carcinoma.