All orthotopic MYC-HCC mice treated with the combination of Ccl2 and Il13 developed intrahepatic metastases (p=0.008, FC 2.5) and multifocal pulmonary metastases (p=0.02, FC = 104.4) (Figure 6c, e and g). This evidence concerns the gene CCL2 and hepatocellular carcinoma.