MYC and hepatocellular carcinoma: Previously, we used the Tet System to generate a conditional transgenic mouse model for MYC-induced HCC that we and others have used to study mechanisms of oncogene addiction (Settleman, 2012) and identify potential therapies (Dhanasekaran et al., 2018; Kapanadze et al., 2013; Ma et al., 2016; Shachaf et al., 2004).