LDHC and breast carcinoma: Indeed, further analyses using a second breast cancer cell line model shows a strong increase in IFN-γ release and cytolytic activity of P11- and P73-primed T cells against BT549 cells with high expression of LDHC (A2 + /high) versus their counterparts after LDHC silencing (A2 + /low) (Supplementary Fig. 2).