Multiple RTKs are upregulated in BRAF-mutant melanoma cells following BRAFi/MEKi38 and may be activated by growth factors derived from the stromal microenvironment.1,13 We show that the next-generation BETi, PLX51107, inhibited BRAFi/MEKi-induced upregulation of two RTKs, ErbB3 and PDGFR-β. This evidence concerns the gene ERBB3 and melanoma.