Previously, we reported that infiltrating MDSC numbers were increased in ID8-Vegf tumour as compared with those in ID8 tumour, which ultimately leads to immunosuppression.9 Tumour-infiltrating Gr-1 + MDSCs are reported to contribute to the resistance to anti-VEGF therapy in another tumour model.27 Taken together, these results indicate that immunosuppression caused by MDSCs is potentially associated with resistance to anti-VEGF antibody. The gene discussed is VEGFA; the disease is neoplasm.