Clinical [12] and experimental evidence [10, 13] suggest causality of IL6 trans-signaling on the inflammatory response in atherosclerosis and data from our group indicate that an excess of the circulating IL6:sIL6R over the ternary IL6:sIL6R:sgp130 complex increases the risk for future cardiovascular (CV) events [14]. This evidence concerns the gene IL6R and atherosclerosis.