WRN and stroke disorder: Only two of the SNPs identified in the present study have formerly been associated with the risk of inflammatory and CV diseases: rs74760246 (chromosome 1), in the intronic region of CRB1, is in strong LD (r2 ≥ 0.8) with rs1421389 and rs10494757 mapping at DENNB1, a gene associated with the risk of chronic inflammatory diseases [17, 18]; rs3087409 (chromosome 8) at WRN, an intronic SNP in full LD with a variant previously associated with premature aging and with the risk of myocardial infarction and stroke [19].