Interestingly, the activator regulates the recruitment of insulin granules and beta-cell function31,32; previous global GWAS associated CADPS loci with treatment interaction of sulfonylurea (a glucose-lowering drug) and heart failure-related metabolite levels21,22; and GTeX annotates the marker as regulating the expression of its own gene (CADPS) in adipose-subcutaneous and tibial artery tissues. The gene discussed is INS; the disease is heart failure.