To explore the mechanisms underlying TH signaling suppression-induced protection, we examined expression of the genes involved in oxidative stress responses, including Gpx4, Nox4, and Ncf1, apoptosis/necroptosis pathways, including Casp3, Casp7, Casp8, Tnfrsf1α, Ripk1, Ripk3, Mik1, and inflammatory responses, including Nirp3, Il-1α/β, Il-6, and Il22. Mice received anti-thyroid treatment and NaIO3 challenge, as described above, and were analyzed for gene expression in the RPE and retina by qRT-PCR at 1 day post-NaIO3 injection. Here, NOX4 is linked to thyroid gland disorder.