Consistent with previous studies concerning renal fibrosis, our results show that inhibition of HIF-1α rescued the reduction of PPARα and CPT1α, suppressed lipid droplets deposition and the synthesis, as well as accumulation of fibronectin and collagen in PTCs, suggest that UCP2-dependent lipid and ECM accumulation is regulated by HIF-1α. Here, PPARA is linked to renal fibrosis.