Whole-exome sequencing of human cutaneous squamous-cell carcinoma (cSCC) has identified this as one of the most mutated human cancers, with a mean of 50 mutations per megabase of DNA (Inman et al., 2018). This sequencing has also revealed that there are significantly more mutations in immune-related pathways, including in FcεRI-signalling, in tumours of high- versus low-risk of metastasis (Inman et al., 2018). This evidence concerns the gene FCER1A and neoplasm.