STAT3 and injury: For example, STAT3 activation by IL-6 potentiates proinflammatory responses in peritoneal macrophages [29], whereas STAT3 activation by IL-10 dampens lipopolysaccharide (LPS)-induced inflammatory responses in Kupffer cells [30, 31], and STAT3 activation by IL-22 ameliorates ethanol-induced liver injury [18].