Moreover, SPRY4-IT1, a long non-coding RNA derived from the second intron of SPRY4 [20], has been shown to interact with SKA2 [21], a gene that was suggested to be a promising biomarker for suicidal behavior [22, 23], stress susceptibility, and stress-related disorders such as PTSD [23–25]. This evidence concerns the gene SPRY4 and post-traumatic stress disorder.