There are many different mechanisms that have been attributed to the diabetes-associated enhanced platelet activation [16], such as a loss of the antiplatelet effect of insulin [17], high blood glucose, oxidative stress [18], elevated vascular shear forces [19], increased binding of fibrinogen [20], altered expression of glycoprotein receptors and proteins attached to the platelet surface [21–23]. The gene discussed is INS; the disease is diabetes mellitus.