Triggering receptor expressed on myeloid cells 1 (TREM-1), a member of immunoglobulin family predominantly expressed on the neutrophils and monocytes, was first identified by Bouchon A. et al in 2000 [5], which is upregulated in response of bacterial and fungal infections but poorly expressed in non-infectious inflammation [6, 7] . Here, TREM1 is linked to fungal infectious disease.