This is in agreement with a clinical study that showed that the plasma level of IL-6 in patients with heart failure was related to its severity.12 To understand the role of myocardial Regnase-1 upregulation during cardiac remodeling, we used the severe TAC model, in which Il6 mRNA showed continuous upregulation until 4 weeks after operation. The gene discussed is IL6; the disease is persistent truncus arteriosus.