The BPIFB1 network from CFBE41o- cells was a first order network consisting of 255 nodes (Fig E in S1 File) and was enriched for immunological pathways including ‘Influenza Infection’, ‘TRAF6 mediated NF-kB activation’, ‘RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways’ and ‘DAI mediated induction of type I IFNs’ (Table F in S1 File). The gene discussed is TRAF6; the disease is influenza.