First, we confirmed that silencing of Vps4a and Vps4b in mouse colon cancer cells recapitulated the synthetic lethality observed in human CRC cells, such that it was accompanied by activation of caspase 7 and canonical NF‐κB signaling leading to cell death (Fig EV5B and C). The gene discussed is CASP7; the disease is malignant colon neoplasm.