To examine whether genetic alterations at the VPS4B locus corresponded to decreased VPS4B protein abundance in CRC, we performed immunohistochemistry (IHC) staining of both paralogs of VPS4 in tissue microarrays covering one hundred pairs of matched human normal colon and treatment‐naïve primary CRC samples (Figs 1E and F, and EV1B). Here, VPS4B is linked to colorectal carcinoma.