In these mice, androgen‐mediated skeletal muscle gene transcription was severely muted in the presence of a cachectic burden, and fully anabolic doses of SARM were unable to normalize tumor‐mediated muscle E3‐ligase expression (atrogin‐1 and MuRF1) to effectively combat the catabolic decline driven by the C‐26 tumor. Here, FBXO32 is linked to neoplasm.