Phosphoglycerate dehydrogenase (PHGDH), the first enzyme of the pathway, is an established oncogene in breast cancer and melanoma (Locasale et al, 2011; Possemato et al, 2011), and when overexpressed in MCF10A spheroids, it leads to the formation of disorganized spheroids with filled lumen (Locasale et al, 2011). This evidence concerns the gene PHGDH and melanoma.