These data showed that diet‐induced obesity synergizes with MMTV‐PyMT in promoting tumour formation and inhibition of IKKε/TBK1 by amlexanox delays tumour appearance in mice on HFD, even when induced by a strong oncogene, such a PyMT. The gene discussed is IKBKE; the disease is obesity due to melanocortin 4 receptor deficiency.