Phosphoglycerate dehydrogenase (PHGDH), the first enzyme of the pathway, is an established oncogene in breast cancer and melanoma (Locasale et al, 2011; Possemato et al, 2011), and when overexpressed in MCF10A spheroids, it leads to the formation of disorganized spheroids with filled lumen (Locasale et al, 2011). The gene discussed is PHGDH; the disease is breast cancer.