Since maintenance of mitochondrial machinery depends on the action of some mitochondria‐related nuclear‐encoded proteins,11 the principal aim of this study was to assess the expression levels PGC1α, TFAM and GSK3β, as well as their predicted upstream miRNA, miR‐376a, in chronic and acute models of PD and patient's peripheral blood mononuclear cells (PBMCs). This evidence concerns the gene TFAM and Parkinson disease.