Nevertheless, It is opposite to a previous study that CTRP9 was shown to trigger hypertrophic cardiac remodelling during pressure overload.20 These results implicate that CTRP9 is in fact playing a permissive role in the complicated development of cardiac hypertrophy especially in the regulation of LKB1/AMPK pathway, which is most likely differently involved in transverse aortic constriction (TAC) vs HFD mouse models. This evidence concerns the gene STK11 and cardiac hypertrophy.