Under some conditions, LKB1 is phosphorylated at Ser428 (pLKB1) and then translocated to the cytosol and subsequently induces activation of AMPK.12 Although several lines of evidence demonstrate that AMPK phosphorylation is attenuated in diet‐induced obesity (DIO) mouse hearts,13, 14 the mechanisms by which AMPK phosphorylation is decreased are not fully elucidated. Here, STK11 is linked to obesity due to melanocortin 4 receptor deficiency.