Our experiments demonstrated HFD feeding markedly increased cardiac hypertrophy, including increases in left ventricular posterior wall thicknesses (LVPWd) and interventricular septum thicknesses (IVSTd), but did not cause cardiac systolic dysfunction (left ventricular ejection fraction [LVEF] and left ventricular shortening fraction [LVFS]) (Figure 3C‐F), which was aggravated by CTRP9 deficiency. The gene discussed is C1QTNF9; the disease is cardiac hypertrophy.